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Physiogenex (France) collaboration
         - Diabetic Nephropathy
About CLEA Japan, Inc.
 
 
 
CLEA Japan has a collaboration project of Diabetic Nephropathy model development with Physiogenex, a French preclinical CRO with expertise in obesity/type 2 diabetes and related complications. We started our project since Physiogenex proposed to develop, validate and use the SDT fatty rat as a novel diabetic nephropathy model.
Presentation Record  (↓Decending order)
Poster Presentation   Kidney Week 2017 - November 3rd, 2017

Poster Title:
Dapagliflozin Alone or Combined with Ramipril Improves Hyperglycemia, Hypertension, and Prevents Kidney Complications and GFR Decline in the Nephrectomized SDT Fatty Rat Model of Diabetic Nephropathy.

Conclusion:
In the 10-week Unx SDT fatty rat under 0.3% salt, DAPA alone prevents kidney complications, while the combination with RAMI adds benefits by better delaying GFR decline. Our data suggest that SGLT2i/ACEi combination prevents progression to ESRD.

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Poster Presentation   ERA-EDTA 2017 - June 5th, 2017
   ISN 2017 - April 23rd, 2017

Poster Title:
10-week, but not 7-week, Dapagliflozin treatment improves sever renal impairment in Uni-Nephrectomized SDT fatty rat, a 10-week model of advanced renal complications and Glomerular filtration rate decline.

Conclusion:
Dapagliflozin for 10 weeks, but not 7 weeks, significantly prevents advanced renal complications in Unx SDT fatty rats. Long-term SGLT2i may be beneficial against kidney complications in the context of type 2 diabetes

← Click here to download the Poster PDF
Poster Presentation   Kidney Week - November 18th, 2016

Poster Title:
Dapagliflozin Improves Glycemic Control, Hypertension and is Neutral on Severe Renal Impairment in Uni-nephrectomized SDT fatty rat, a 10-week Model of Advanced Renal Complications and Glomeurular Filtratin Rate Decline.

Conclusion:
Unilateral nephrectomy and salt supplementation in SDT fatty rat expedite renal complications resulting in a >50% GFR decline in only 10 weeks. Our data suggest that SGLT2i with DAPA has no detrimental effect in uni-nephrectomized SDT fatty rat with advanced renal complications and >50% GFR decline.

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Poster Presentation   New York Academy of Sciences - September 8th, 2016

Poster Title:
Unilateral Nephrectomy and Salt Supplementation in Spontaniously Diabetic Torii Fatty Rat Expedite Renal Complications and Glomerular Filtration Rate Decline within 10 Weeks.

Conclusion:
Unilateral nephrectomy and salt supplementation in SDT fatty rat expedite renal complications resulting in a >50% GFR decline in only 10 weeks. The SDT fatty rat therefore represents a robust model to evaluate drugs targeting diabetic nephropathy. Anti-diabetic SGLT2 inhibitor dapagliflozin and anti-hypertensiove ACE inhibitor ramipril are currently under evaluation.

← Click here to download the Poster PDF
 
 
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